The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues
Figure 5
Validation of LKB1 antibody in situ assay in human lung tumor specimens.
A, LKB1 protein expression vs. gene expression scores. Researchers used the Agilent 44(p<0.01). B, Box plots showing comparison of gene expression scores in cases with confirmed LKB1 loss-of-function mutations vs. cases with no mutations. C, Protein expression by mutation status providing visual comparison of cases with mutation vs. no mutation. The x-axis shows the percentage of cases per LKB1 score (i.e. each side adds up to 1). The unsymmetrical shape indicates differences between the groups.