Ghrelin Receptor (GHS-R1A) Antagonism Suppresses Both Alcohol Consumption and the Alcohol Deprivation Effect in Rats following Long-Term Voluntary Alcohol Consumption
Figure 3
Acute JMV2959 treatment decreases alcohol preference in rats.
(A) Acute administration of the GHS-R1A antagonist JMV2959 (1 or 3 mg/kg) decreases the alcohol preference compared to vehicle at 1 hour time interval in rats voluntarily consuming alcohol for two and five months before the treatment. Acute administration of the GHS-R1A antagonist JMV2959 (1 or 3 mg/kg) decreases the alcohol preference compared to vehicle at 4 hour time interval in rats voluntarily consuming alcohol for two and five months before the treatment. All values represent mean alcohol preference (%) ± SEM (n = 19, *P<0.05, **P<0.01, ***P<0.001 compared to corresponding vehicle or as indicated).