S-Nitrosoglutathione Reductase Inhibition Regulates Allergen-Induced Lung Inflammation and Airway Hyperreactivity
Figure 7
Schematic representation of the anti-inflammatory effects mediated by GSNOR inhibition in asthma.
Nitric Oxide produced by a nitric oxide synthase reacts with glutathione to form S-nitrosoglutathione. This reactive molecule promotes bronchodilation and anti-inflammatory effects, and is ultimately degraded to oxidized glutathione and ammonia by S-nitrosoglutathione reductase (GSNOR). We propose that inhibition of GSNOR (which is over-expressed in inflammatory states and asthma) using the GSNOR inhibitor SPL-334 will increase steady-state levels of S-nitrosoglutathione and thus inhibit inflammation and AHR.