S-Nitrosoglutathione Reductase Inhibition Regulates Allergen-Induced Lung Inflammation and Airway Hyperreactivity
Figure 6
Treatment with the GSNOR inhibitor reduced CCL11 production during allergic lung inflammation.
LMCs were obtained from control mice and Th2 recipient mice that have been treated with either SPL-334 or vehicle and inhaled OVA for 7 d. (A) LMCs were stimulated with anti-CD3 (2 µg/ml) or OVA323–334 peptide (1 µg/ml) for 24 h and supernatant analyzed for eotaxin production by ELISA. (B) CCL11 levels in the BALF were measured by ELISA. Results are mean ±SE of four to six individual mice analyzed per group in triplicates and are representative two independent experiments. *p, 0.05, compared with Th2 group.