S-Nitrosoglutathione Reductase Inhibition Regulates Allergen-Induced Lung Inflammation and Airway Hyperreactivity
Figure 4
Treatment with the GSNOR inhibitor caused a reduction in AHR
. DO11.10 CD4+ Th2 cells were transferred into BALB/c mice that were then challenged with aerosolized OVA for 7 d. Mice were treated with either SPL-334 (Th2+ SPL-334) or vehicle (Th2). Control mice did not receive Th2 cells but inhaled OVA aerosols. Lung resistance (RL) and dynamic compliance (CDyn) was assessed in anesthetized and tracheotomized mice that were mechanically ventilated in response to increasing concentrations of methacholine inhalation. Data are mean ±SE of ten individual mice analyzed per group. *p, 0.05, compared with Th2 group.