S-Nitrosoglutathione Reductase Inhibition Regulates Allergen-Induced Lung Inflammation and Airway Hyperreactivity
Figure 3
GSNOR inhibitor caused a reduction in peribronchial inflammation and mucus secretion during airway inflammation.
DO11.10 CD4+ Th2 cells were transferred into BALB/c mice that were then challenged with aerosolized OVA for 7 d. Mice were treated with either SPL-334 (Th2+ SPL-334) or vehicle (Th2). Control mice did not receive Th2 cells but inhaled OVA aerosols. (A) Peribronchial inflammation and (B) mucus production were determined by histological analysis by staining lung tissue sections with H&E or PAS, respectively (20x). PAS staining was expressed as % PAS+ area per bronchiole, and bronchial wall thickness expressed in µm. Data are representative of two separate experiments. *p, 0.05, compared with Th2 group.