Analysis of 953 Human Proteins from a Mitochondrial HEK293 Fraction by Complexome Profiling
Figure 4
Representative hierarchical clustering results of mitochondrial protein profiles.
Profiles from proteins with mitochondrial annotation (MITOP2 reference dataset or Gene Ontology) or mitochondrial prediction (MITOP2 SVM) were subjected to hierarchical clustering (uncentered Pearson's correlation metric, optimized leaf order, and complete linkage distance). Five representative clusters are shown that contain the five mitochondrial oxidative phosphorylation system (OXPHOS) complexes. Clusters that are referenced in the text are indicated in the HCL tree with numbers that correspond with cluster numbers defined by the MEV software.