Plant Derived Aporphinic Alkaloid S-(+)-Dicentrine Induces Antinociceptive Effect in Both Acute and Chronic Inflammatory Pain Models: Evidence for a Role of TRPA1 Channels
Figure 6
Effect of S-(+)-dicentrine (DCTN) administered by oral route (10 - 100 mg/kg, panels A and B) or by intraplantar route (10 - 100 µg/paw, panels C and D), or the TRPA1 antagonist camphor by subcutaneous (7.6 mg/kg) or intraplantar (3.8 µg/paw) routes on cinnamaldehyde-induced nociception.
Panels A and C represents the spontaneous nociception (licking time) and panels B and D represents the hypersensitivity to cold (latency time to paw withdrawal). Each bar represents the mean ± S.E.M. of 6 - 8 animals, being column C indicative of control values (cinnamaldehyde i.pl. injection) and column V indicative of group receiving only vehicle i.pl. injection. Significance levels are indicated by ***p<0.001 when compared to vehicle (V) group and ##p<0.01 and ###p<0.001 when compared to respective control (C) groups, and the values above the symbols represent the percent of inhibition (one-way anova and Student-Newman-Keuls post hoc test).