Plant Derived Aporphinic Alkaloid S-(+)-Dicentrine Induces Antinociceptive Effect in Both Acute and Chronic Inflammatory Pain Models: Evidence for a Role of TRPA1 Channels
Figure 4
Effect of S-(+)-dicentrine (DCTN) administered by oral (100 mg/kg) or intraplantar (100 µg/paw) routes, or the TRPV1 antagonist AMG9810 by intraperitonial (30 mg/kg) or intraplantar (30 µg/paw) routes on capsaicin-induced nociception.
Each bar represents the mean ± S.E.M. of 6 - 8 animals, being column C indicative of control values. Significance levels are indicated by **p<0.01 when compared to control group (one-way anova and Student-Newman-Keuls post hoc test).