Plant Derived Aporphinic Alkaloid S-(+)-Dicentrine Induces Antinociceptive Effect in Both Acute and Chronic Inflammatory Pain Models: Evidence for a Role of TRPA1 Channels
Figure 2
Effect of S-(+)-dicentrine (DCTN, 100 mg/kg, p.o.) on mechanical hypersensitivity induced by CFA 80%.
Panel A: time-course effect of DCTN evaluated at 1, 2, 3, 4 and 24 hours post-DCTN administration; each point represents the mean ± S.E.M. of 10 animals and significance levels are indicated by *p<0.05 and ***p<0.001 when compared to the CFA i.pl. group (two-way anova and Bonferroni post hoc test). Panel B: effect of DCTN on 7th and 10th days post-CFA injection, evaluated before DCTN administration (basal) and 1 hour post-DCTN administration; each bar represents the mean ± S.E.M. of 10 animals and significance levels are indicated by ***p<0.001 when compared to control group and ##p<0.01 when compared to the respective basal of CFA i.pl. group (one-way anova and Student-Newman-Keuls post hoc test).