Plant Derived Aporphinic Alkaloid S-(+)-Dicentrine Induces Antinociceptive Effect in Both Acute and Chronic Inflammatory Pain Models: Evidence for a Role of TRPA1 Channels
Figure 1
Effect of S-(+)-dicentrine (DCTN, 100 mg/kg, p.o.) on mechanical hypersensitivity induced by CFA 50%.
On 1st and 14th days, evaluations were done 1, 2, 3, 4 and 24 hours post-DCTN treatment; all other evaluations were done 1 hour post-treatment. Each point represents the mean ± S.E.M. of 8 animals and significance levels are indicated by *p<0.05 and **p<0.01 when compared to the CFA i.pl. group (two-way anova and Bonferroni post hoc test).