Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions
Figure 1
Dabrafenib structure and activity against RAF kinases.
Dabrafenib chemical structure (A). Dabrafenib potency (IC50) was measured against the kinase activity of various BRAF orthologs, human BRAF mutants, and human CRAF (B).