Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins
Figure 4
Cherry-picked chemical compound library screen with Yes-NANOMS.
(A) Chemical structures of chemical compounds that were included in the cherry-picked chemical library. (B) BHK21 cells were transfected with Yes-NANOMS and screened with shown chemical compounds at a final concentration of 10 µM/mL. FRET-response of Yes-NANOMS to the chemical compounds is represented with Emax values. Block line indicates the average Emax and the error bars denote the s.e.m (n≥4). Samples were statistically compared with the untreated control. See Methods for more on statistical analysis.