TRPV1 and TRPV4 Play Pivotal Roles in Delayed Onset Muscle Soreness
Figure 5
Muscular mechanical hyperalgesia was not developed after NGF injection in TRPV1−/− mice.
Change in the withdrawal threshold by intramuscular injection of NGF-2.5 S was measured by RST. Vertical axis: difference in the withdrawal threshold from that before NGF-injection, horizontal axis: time after injection. WT mice (closed circles), TRPV1−/− mice (crosses) and TRPV4−/− mice (open squares). *** p<0.001 compared with −1 d (Bef. in the figure) in WT;+p<0.05,++p<0.01 compared with −1 d in TRPV4−/−; two-way repeated measures ANOVA with Bonferroni t-test.