Rosiglitazone Treatment of Type 2 Diabetic db/db Mice Attenuates Urinary Albumin and Angiotensin Converting Enzyme 2 Excretion
Figure 2
Chronic treatment with rosiglitazone attenuated glucose excretion, albuminuria and plasma creatinine levels in db/db mice.
(A) Urinary glucose excretion in lean control, db/db and db/db+rosiglitazone mice. One-way ANOVA showed that urinary glucose excretion increased in db/db mice compared to lean controls (*p<0.001). Eight weeks after treatment commenced there was a significant decrease in urinary glucose excretion of db/db+rosiglitazone mice compared to untreated db/db mice. #p<0.001 Vs untreated db/db mice. Each bar represents mean ± SEM of group size (n = 6–8). (B) Urinary albumin excretion in control, rosiglitazone treated and untreated db/db mice 2 wks, 4 wks, 6 wks and 8 wks after the commencement of treatment. Repeated measures two-way ANOVA using a Bonferroni’s posthoc test showed that treatment resulted in a significant decrease in urinary albumin excretion of db/db+rosiglitazone mice [F (1, 20) = 36.004], p<0.0001. Similarly, duration of treatment showed a significant decrease in urinary albumin excretion of db/db+rosiglitazone mice after 2 wks, 4 wks, 6 wks and 8 wks of treatment [F (2, 20) = 7.70], p<0.001. *p<0.05 Vs age-matched lean control mice. #p<0.001 Vs untreated db/db mice. $p<0.05 Vs 2 wks untreated db/db mice. γp<0.05 4 wks Vs 8 wks untreated db/db mice. Each bar represents mean ± SEM of group size (n = 6–7).