Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin
Figure 2
H+E stained skin sections of mice after treatment with retinoid receptor-specific agonists and antagonists.
Representative photographs of H+E stained skin sections from mice topically treated with vehicle control (acetone), or various retinoid receptor-selective agonists or antagonists for 14 days. Note the epidermal thickness of mice treated with synthetic agonists for RXR or RARγ, and appearing most pronounced in the RAR agonist (ATRA) treated group. Epidermal thickness seemed comparable to vehicle control in mice treated with RARα agonist, RXR antagonist, RAR antagonist, and selective antagonists of RARα or RARγ. Original magnification (×20) was digitally magnified. 1all-trans retinoic acid/ATRA.