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Inhibition of the Receptor Tyrosine Kinase ROR1 by Anti-ROR1 Monoclonal Antibodies and siRNA Induced Apoptosis of Melanoma Cells

Figure 5

Transfection of melanoma cells (n = 6) using ROR1 suppressing siRNA.

Downregulation of ROR1 mRNA (RT-PCR) (A). Downregulation of the ROR1 protein (130 kDa) expression (B). (−) untreated cells, (C) control siRNA treated cells, (+) ROR1 siRNA treated cells.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0061167.g005