Alternating Hemiplegia of Childhood-Related Neural and Behavioural Phenotypes in Na+,K+-ATPase α3 Missense Mutant Mice
Figure 5
Thalamocortical, thalamostriatal and intrathalamic functional connectivity in Myk/+ mice.
Summary diagrams showing altered functional connectivity of (A) frontal cortex (FCTX), (B) ventral anterior thalamic nucleus (VAthal), (C) ventromedial thalamic nucleus (VMthal), and (D) ventral posteromedial nucleus (VPMthal) in Myk/+ mice. Only regions where the 95% CI of the VIP exceeded 0.80, in either Myk/+ or +/+ mice, were considered to be functionally connected to the defined “seed” region of interest. The I810N Myshkin mutation-induced alterations in functional connectivity were analysed by permutation test (1000 random permutations of the real data) with significance set at P<0.05. Red denotes a significant increase, whereas blue denotes a significant decrease, in regional functional connectivity in Myk/+ mice relative to +/+.