Antifungal Efficacy during Candida krusei Infection in Non-Conventional Models Correlates with the Yeast In Vitro Susceptibility Profile
Figure 8
Histopathology of G. mellonella infected with C. krusei and C. albicans and treated with different antifungals.
Galleria mellonella was infected with 5×105 cells/larva of C. albicans SC5314 (C–H), or with 5×106 cells/larva of C. krusei ATCC 6258 (K–P). After 96 hours of infection, larvae were processed for histopathology as described in Material and Methods. (A, B, I, J), uninfected controls; (C, D, K and L), untreated controls; (E, F, M and N), larvae treated with fluconazole (12 mg/kg); (G, H, O and P), larvae treated with amphotericin B (4 mg/kg). (A, C, E, G, I, K, M, O), low magnification; (B, D, F, H, J, L, N and P), high magnification.