Excisional Wound Healing Is Delayed in a Murine Model of Chronic Kidney Disease
Figure 9
Quantitative reverse-transcription PCR (qRT-PCR) of growth factor, nitric oxide, and inflammatory genese.
Genetic analysis of wounds by qRT-PCR exhibited differences in expression of important wound healing related genes due chronic kidney disease. At post-operative day (POD) 3, CKD wounds demonstrate significantly reduced expression of VEGF and eNOS, with an increase in IL-1β. These trends were maintained at POD7, except for a significant decrease in iNOS instead of eNOS. Rows show POD when the tissue was collected, POD0, 3, and 7 at top, middle and bottom, respectively. Genes analyzed are represented by columns: (A) growth factor genes, (B) nitric oxide genes and (C) cytokine genes. (* p<0.05) (n = 4 wounds/group).