E47 and Id1 Interplay in Epithelial-Mesenchymal Transition
Figure 5
E47 and ID factors are preferentially expressed in basal-like breast carcinomas.
(A) Unsupervised hierarchical clustering of the vant’Veer dataset (ref. 36) for the expression of the indicated basal and luminal markers, together with estrogen (ESR1) and progesterone receptors (PGR) and ErbB2, identifies two clusters of basal (yellow) and non-basal (purple) tumours. Increased TCF3 and ID1/ID4 transcripts cluster with the basal-like subgroup. (B) Association between the expression of TCF3 and ID1/ID4 with the basal-like phenotype in the vańt Veer's dataset. To validate the association among specific genes and/or tumour subgroups, each variable was categorized using the percentile 75 value as the cut-off. (C) Overexpression of TCF3 associated to basal-like breast tumours (upper) and to decreased overall survival (bottom) in the indicated public datasets.