The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor
Figure 3
Representative Ki determination for methoxetamine in an NMDA receptor assay compared with reference compound MK-801 (dizocilpine).
Shown are results from a typical experiment wherein methoxetamine Ki values were determined (Ki = 337+/−76 nM; N = 3 separate determinations of this type) and MK-801 (Ki = 5.7+/−0.57 nM; N = 3 separate determinations of this type).