Malate and Fumarate Extend Lifespan in Caenorhabditis elegans
Figure 4
Malate-induced lifespan extension requires fumarase and the glyoxylate cycle.
(A) 10 mM malate treatment did not alter the lifespan of glyoxylate cycle gei-7 RNAi knockdown N2 worms (log-rank p = 0.24). (B) 10 mM fumarate treatment decreased the lifespan of glyoxylate cycle gei-7 RNAi knockdown N2 worms (log-rank p = 0.02). (C) 10 mM malate treatment did not alter the lifespan of fumarase (fum-1) RNAi knockdown N2 worms (log-rank p = 0.49). (D) 10 mM fumarate treatment increased the lifespan of fumarase (fum-1) RNAi knockdown N2 worms (log-rank p<0.001).