Malate and Fumarate Extend Lifespan in Caenorhabditis elegans
Figure 3
Adding malate to the media increased lifespan of C. elegans RNAi knockdown strains.
(A) 10 mM malate increased lifespan of skn-1 RNAi knockdown N2 worms (log-rank p = 0.03). (B) 10 mM malate increased the lifespan of malic enzyme (men-1) RNAi knockdown N2 worms (log-rank p<0.001). (C) 10 mM malate increased the lifespan of mitochondrial malate dehydrogenase (mdh-1) RNAi knockdown N2 worms (log-rank p<0.001). (D) 10 mM malate increased the lifespan of cytoplasmic malate dehydrogenase F46E10.10 RNAi knockdown N2 worms (log-rank p = 0.006).