Effects of Cyclic Intermittent Hypoxia on ET-1 Responsiveness and Endothelial Dysfunction of Pulmonary Arteries in Rats
Figure 5
Effects of CIH on pulmonary arteries histopathological changes.
Representative microscopic photographs of pulmonary arteries stained with H&E (magnification 400×) (A and B) and TEM (C and D). Pulmonary arteries obtained from normoxia group (A and C) and CIH group (B and D). In the pulmonary artery segments from the CIH group, there were histopathological changes of the endothelial monolayer with cellular enlargement and edema, denudation of some endothelial cells. The ultrastructure was observed by TEM in the (C) normoxia group and (D) CIH group. Large defects of the endothelial layer, cellular vacuolation and mitochondrial damage could be observed in D.