Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity and Sinoatrial Nodal Pacemaker Cell Energetics
Figure 5
(A) CaMKII inhibition by KN-93 or AIP, or calmodulin inhibition by W-7 decreases O2 consumption in SANC suspension (n = 5 for each drug), (B) AIP decreases mitochondrial flavoprotein fluorescence in single SANC (representative example), indicating a net reduction of flavoprotein pool.
Washout of AIP reverses this effect. *p<0.05 vs. drug control.