Differential MicroRNA Regulation Correlates with Alternative Polyadenylation Pattern between Breast Cancer and Normal Cells
Figure 2
Correlation among expression level, shortened fraction and LSR.
(A) Box plot for log2 ratios of mRNA expression levels between MCF-7 and MCF-10A cells of the shortened genes reported by Fu et al., 2011. Expression level is the total read count of all isoforms for each gene. (B) Box plots for log2 ratios of mRNA expression levels between MCF-7 and MCF-10A cells against shortened fraction in MCF-7 cells. For each gene, shortened fraction is calculated by dividing average shifted length in MCF-7 by weighted 3′ UTR length in MCF-10A. All data originate from Fu et al., 2011. (C) Scatter plot for mRNA expression level versus LSR between MCF-7 and MCF-10A cells of all APA genes (y-axis: log2 ratio of mRNA expression level between MCF-7 and MCF-10A cells; x-axis: log2 ratio of LSR, where the lower the value, the higher the proportion of short isoform in MCF-7 versus MCF-10A). A positive correlation can be observed. The red dashed line denotes the linear regression line.