Warburg and Crabtree Effects in Premalignant Barrett's Esophagus Cell Lines with Active Mitochondria
Figure 5
Barrett's esophagus progression to esophageal adenocarcinoma involves an intermediate metabolic stage with increased glycolysis and functional mitochondria.
Early-stage BE cells (e.g. CP-A), rely mainly on mitochondrial oxidative phosphorylation for energy needs prior to the glycolytic increase which occurs in late-stage BE cells (CP-B, CP-C and CP-D), which demonstrate elevated ECAR (all) and the Crabtree effect (CP-C and CP-D). Finally in esophageal adenocarcinoma (OE-33) mitochondrial uncoupling occurs with increased OCR and glycolysis.