TWEAK Enhances E-selectin and ICAM-1 Expression, and May Contribute to the Development of Cutaneous Vasculitis
Figure 1
TWEAK and Fn14 are upregulated in LPS-induced CV.
BALB/c mice were treated with LPS or equal volume of PBS s.c. into the left ear and challenge with LPS 150 µg or PBS i.p. respectively 24 h later. 6 h after challenge, sera and tissue samples were collected. (ten mice per group). (A) Serum TWEAK levels were determined by ELISA. Values are expressed as Mean ± SD. P-values are based on the Mann–Whitney U-test. (B) The expression of TWEAK and its receptor Fn14 on endothelial cells in the skin were detected by immunohistochemistry. Scale bars, 50 µm.