High-Throughput Screening for Growth Inhibitors Using a Yeast Model of Familial Paraganglioma
Figure 5
Structures and yeast growth curves in galactose:glycerol (1∶1) medium showing differential growth inhibition of sdh2Δ mutant yeast for four non-reactive compounds from main library HTS.
A. 7619814 (50 µM). B. 7172827 (50 µM). C. 7783421 (25 µM). D. 4032-1245 (6 µM). Solid lines: growth in the absence of drug for WT (black) and sdh2Δ mutant (red). Dashed lines: growth in the presence of the indicated drug concentration.