Distinct Spatiotemporal Expression of Serine Proteases Prss23 and Prss35 in Periimplantation Mouse Uterus and Dispensable Function of Prss35 in Fertility
Figure 5
Deletion of Prss35 on embryo implantation and the expression of implantation markers in D4.5 uterus.
A. A representative uterus from D4.5 WT mice. B. A representative uterus from D4.5 Prss35(−/−) mice. A & B. Red arrows, implantation sites. C. The average number of implantation sites per mouse in the WT (+/+, N = 8) or Prss35(−/−) (−/−, N = 8) females. All the mating males were Prss35(−/−) for both groups except 2 WT males mated with 2 females in the WT group. Error bars, standard deviation. D∼K. Gene expression in D4.5 uterus by in situ hybridization. D. Prss35 in WT uterus. E. Prss35 in Prss35(−/−) uterus. F. Gjb2 in WT uterus. G. Gjb2 in Prss35(−/−) uterus. H. Gja1 in WT uterus. I. Gja1 in Prss35(−/−) uterus. J. Cox-2 in WT uterus. K. Cox-2 in Prss35(−/−) uterus. Red star, embryo; LE, luminal epithelium; Dec, decidual zone; scale bars, 100 µm.