The Relationship between Cortical Blood Flow and Sub-Cortical White-Matter Health across the Adult Age Span
Figure 5
Surface-based analyses of associations between regional DTI parameters in the corpus callosum and cortical CBF.
Significant positive associations are shown in orange-yellow, inverse associations are shown in blue. (a) Significant positive and spatially specific associations between FA and CBF can be seen. In contrast, AD and RD were negatively correlated with cortical CBF. (b) Strong associations remained after statistically controlling for age in the analyses. Regional associations did not follow patterns of known anatomy based on white-matter fibre trajectories or known vascular structure. However, cortical regions where CBF was associated with white matter integrity did exhibit qualitative similarities with the medial regions within the “default-mode” brain network.