Micro-MRI Study of Cerebral Aging: Ex Vivo Detection of Hippocampal Subfield Reorganization, Microhemorrhages and Amyloid Plaques in Mouse Lemur Primates
Figure 2
Analysis of hippocampal subfield volumes.
(A) Segmentation of the hippocampus, divided into the dentate gyrus and the extended Ammon's horn (includes CA1, CA2, CA3, CA4 and subiculum), based on the mouse lemur brain atlas [48]. No correlation was found between age and total hippocampal volume (B), however, we observed a significant decrease with age of the normalized volume of the extended Ammon's horn (C), and a significant increase with age of the normalized volume of the dentate gyrus (D). (E–F) 3D views of hippocampal subfields in one young (E) and one old animal (F), showing the increased volume of the dentate gyrus and decreased volume of the Ammon's horn in the aged lemur as compared to the young one.