1′-Acetoxychavicol Acetate Isolated from Alpinia galanga Ameliorates Ovalbumin-Induced Asthma in Mice
Figure 5
ACA reduced expression of Th2 and Th1 cytokines in OVA-induced asthma.
Treatment with ACA reduced (a) IL-13 expression and (b) almost completely blocked IL-4 expression in the lungs. (c) ACA also decreased IL-5 expression but to a lesser extent. (d) ACA almost completely blocked IL-12α expression and (e) downregulated IFN-γ expression. Immunopositive cells were counted in five randomly selected nonoverlapping fields (×200 magnification) of three separately immunostained lung sections per each animal. A, vehicle control; B, OVA-induced asthma model; C, dexamethasone; D, 25 mg/kg/day ACA; E, 50 mg/kg/day ACA. Results are expressed as mean ± SD (n = 7 per group);*p<0.05 and **p<0.01 vs. OVA group.