1′-Acetoxychavicol Acetate Isolated from Alpinia galanga Ameliorates Ovalbumin-Induced Asthma in Mice
Figure 2
ACA dose-dependently inhibited histopathological changes in the lungs of mice with OVA-induced asthma.
(a) ACA dose-dependently reduced inflammatory cell infiltration around vessels and bronchioles, mucus secretion and cell debris in bronchioles, and goblet cell hyperplasia in the lungs. Bar size, 50 μm; hematoxylin and eosin stain. (b) ACA dose-dependently decreased bronchial secretion of glycoproteins in OVA-induced asthma. Bar size, 50 μm; PAS stain. Arrow: inflammatory cell infiltration. Br, bronchiole; Gc, goblet cell; M, mucus secretion; V, vessel. A, vehicle control; B, OVA-induced asthma model; C, dexamethasone; D, 25 mg/kg/day ACA; E, 50 mg/kg/day ACA.