Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice
Figure 5
Enhanced AT8 immunopositive neuronal perikarya in Tg-FDD-Tau mice.
Staining of a section of the neocortex of a 6 month old Tg-Tau mouse (A) and a Tg-FDD-Tau (B) mouse. A statistically significant difference in the number of AT8-positive neuronal perikarya is observed between Tg-FDD-Tau (2x) mice and single Tg-Tau (Tau) mice (C) (****P<0.0001, two tail t test). Immunohistochemistry using Ab AT8 (A, B). Scale bars: A, B, 50 µm.