Suppression of Hepcidin Expression and Iron Overload Mediate Salmonella Susceptibility in Ankyrin 1 ENU-Induced Mutant
Figure 5
Ity16 mutant mice present elevated blood urea nitrogen (BUN), alanine transaminase (ALT) and asparatate transaminase (AST) during Salmonella infection.
BUN (A), ALT (B) and AST (B) levels were measured at day 0 (prior to infection) and day 2 post infection in 7 week old Ank1+/+ wild type, Ank1+/Ity16 heterozygous and Ank1Ity16/Ity16 mutant mice. The values for each individual mouse are shown (n = 3–8 per genotype). Wild type mice are represented by open circles, heterozygous by gray circles and Ity16 mutant by black circles. The high levels of BUN levels detected in mutant mice at day 0 most probably reflect the nephrotoxicity of iron accumulation in the kidney. During infection BUN, ALT and AST levels increased in mutant mice denoting kidney and liver damage. An *represents a P-value of less than 0.05; *** represents a P-value of less than 0.0001.