Suppression of Hepcidin Expression and Iron Overload Mediate Salmonella Susceptibility in Ankyrin 1 ENU-Induced Mutant
Figure 2
Ity16 mutant mice present massive splenomegaly, moderate increase in kidneys and heart weights and bilirubinemia.
A) Body weight of wild type littermates and Ity16 mice by sex (males are represented by squares, females by circles) at 7 weeks (open and black fill) and 24 weeks (open and black fill) n = 3 per sex and genotype. B) Serum bilirubin levels were measured at day 0 and day 2 post infection in wild type (open circle), heterozygous (gray circle) and Ity16 mutant (black circle) mice. C) Increased spleen, kidney and heart weights in Ity16 mutant (black fill) mice compared to wild type littermates (open fill). The data are presented by sex (males are squares, females are circles). Results are representative of at least two experiments. An * represents a P-value of less than 0.05; ** represents a P-value of less than 0.001; *** represents a P-value of less than 0.0001.