Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties
Figure 6
INaP evoked by ramps with different slopes.
Current traces are shown under control conditions (A) and in the presence of PHT (100 µM) (B). The amplitude of the current decreased with the duration of the ramps and the inhibitory effect of phenytoin became clear and significant for INaP evoked by slower ramps (arrows). The inset shows a graphical comparison of INaP amplitude in the different conditions. The graph in C displays the mean values of the INaP peaks measured on five neurons in response to 100, 50 and 10 mVs−1 ramps under control conditions, in the presence of PHT and after PHT wash out.