Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties
Figure 3
Effect of PHT on the voltage-dependence of INaP inactivation.
A, effect of 100 µM PHT on the activation curve; the inset shows the stimulus protocol (prepulses were 10 s in duration; ramps had a slope of 50 mV s−1). Panels B, C and D show the current peaks evoked after different prepulses in a representative neuron. In the presence of PHT, the currents evoked after inactivating prepulses at −40 and −20 mV are clearly reduced with respect to those evoked under control conditions, and partially recover during PHT washout.