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Adaptation to Experimental Jet-Lag in R6/2 Mice despite Circadian Dysrhythmia

Figure 2

Amplitude of the daily activity cycle, averaged over every 7 day period.

Results are shown from mice being kept under constant LD conditions (A), subjected to repeated phase shifts (B), and following jet-lag phase-advance (C) and phase-delay (D). WT mice are shown as open symbols. R6/2 mice are represented by filled symbols. Data are means ± SEM. * = p<0.05, ** = p<0.01, *** = p<0.001.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0055036.g002