A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors
Figure 5
Effect of LC06 and LC08 on quiescent vessels.
(A) Representative immunofluorescent pictures of CD31 stained tracheal whole mount sections of mice treated with control IgG1, LC06 and LC08. (B) Quantification of capillary branching points (in five random regions of 230×520 µm in each mouse whole mount trachea) reveals that pan-Ang-1/Ang-2 inhibition but not selective anti-Ang-2 treatment induced tracheal vessel regression (n = 3–5; *p<0.05 compared to control, Student's t-test). The results were confirmed in two independent experiments. Results are expressed as mean ± SEM. Scale bar represents 100 µm.