A Comparison of Ku0063794, a Dual mTORC1 and mTORC2 Inhibitor, and Temsirolimus in Preclinical Renal Cell Carcinoma Models
Figure 3
Ku0063794 and temsirolimus decreased the viability of RCC cells.
Caki-1 (A, B) and 786-O (C, D) cells were plated on 96-well tissue-culture plates and then treated with Ku0063794 (A, C) or temsirolimus (B, D) at the indicated concentrations or DMSO (vehicle control) for 24 to 96 hours. Cell viability was calculated as a percent of the control and reported as a function of treatment time and drug concentration. The error bars indicate the standard error of the mean for experiments performed in triplicate.