Photo(chemo)therapy Reduces Circulating Th17 Cells and Restores Circulating Regulatory T Cells in Psoriasis
Figure 5
Th17 level is higher in severe and poor-responder patients, Treg level is higher in responder patients.
(A) Psoriasis patients were grouped according to PASI score: 0≦PASI<10; 10≦PASI<20; 20≦PASI<30; 30≦PASI. Dot plots show the levels of Th17 or Treg in each group. Th17 levels in the patients with more than 30 PASI were significantly higher as compared to controls. Horizontal bar indicates mean value. (B) Psoriasis patients were grouped in each treatment group achieving 50%, 75% improvement PASI score from baseline (PASI 50, PASI 75). Dot plots show the levels of Th17 after treatment in each group and controls. Th17 levels after treatment in the patients not achieving PASI 50 were significantly higher than those in the patients achieving PASI 75. (C) Psoriasis patients were grouped according to the amount of decrease in Th17 levels by photo(chemo)therapy: Th17 high increased group n = 16, ΔTh17>1%; Th17 increased group n = 15, ΔTh17>0%; Th17 decreased group n = 24, ΔTh17<0%; Th17 high decreased group n = 13, ΔTh17<−1%. Dot plots show the levels of Treg prior to treatment in each group and controls. The levels of Treg prior to treatment with Th17 high decreased group; ΔTh17<−1% (5.16±2.20%) were significantly higher than that with Th17 high increased group; ΔTh17>1% (3.33±1.39%).