Disease Progression and Phasic Changes in Gene Expression in a Mouse Model of Osteoarthritis
Figure 5
Global view of the differentially expressed genes in the sham time course.
A) A heat map illustrates that the majority of differentially expressed genes (406 probe sets for 347 genes), in the sham time course are down-regulated, with few being up-regulated over time. Heat map rows represent genes, and columns represent replicates of each time points. Red indicates up-regulation, blue down-regulation and white indicates no change in gene expression from the respective control (see Methods). B) Gene expression distributions of the sham time course exhibit a uni-modal distribution throughout the experiment; however, the distributions center becomes shifted toward the negative side of zero at 4 weeks, indicating a global down-regulation of these genes over time due to aging. An SLR of zero is marked by a vertical line on the graph, and replicate time courses are colored as follows: replicate 1 = black, replicate 2 = blue, replicate 3 = red.