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Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Histologic and Transcriptomic Characterization and Correlation to IBD

Figure 5

Differential expression analysis of the TNBS transcriptome.

(A) Scatter plot of the Principal Component Analysis of 8316 genes in response to TNBS. (B) Expression profiles of genes assigned to the 13 clusters of similar expression (see Table S1). Only differentially expressed genes are included. (C) Heat map visualizing functional enrichment of the 13 clusters for over-represented Gene Ontology Biological Process terms. Darker shades represent a greater degree of enrichment.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0054543.g005