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Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients

Figure 5

Enzyme kinetics of glucuronidation of belinostat by UGT1A1.

The apparent Km and Vmax values for the glucuronide formation were 99.6 µM and 353.1 pmol/min/mg protein, respectively.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0054522.g005