Sulodexide Decreases Albuminuria and Regulates Matrix Protein Accumulation in C57BL/6 Mice with Streptozotocin-Induced Type I Diabetic Nephropathy
Figure 2
The effect of sulodexide on albuminuria and renal function in control and DN C57BL/6 mice.
(A) Urine albumin-to-creatinine (ACR) ratio, (B) serum creatinine level and (C) serum urea level in control and DN mice treated with saline or sulodexide are shown. Results are expressed as mean+SD of data obtained from 6 mice per group. Insert in (A) shows the effect of sulodexide on ACR in mice with microalbuminuria (white circle) and macroalbuminuria (black circle) with time. *P<0.01, **P<0.001, with vs without DN for the same time-point, #P<0.01, DN baseline vs sulodexide-treated DN mice, §P<0.001, DN baseline vs saline-treated DN mice, ‡P<0.01, saline vs sulodexide treatment for the same time-point.