Transgenic Overexpression of 14-3-3 Zeta Protects Hippocampus against Endoplasmic Reticulum Stress and Status Epilepticus In Vivo
Figure 5
Baseline and seizure EEG in 14-3-3ζtg mice.
(A). Protein levels of the kainic acid receptors GluR6/7 and KA2 in microdissected subfields of hippocampus from wt and 14-3-3ζtg mice. (B) Analysis of baseline EEG parameters during 40 min recordings from skull of wt and 14-3-3ζtg mice. No differences were detected between genotypes (n = 6 per group). (C) Representative EEG spectral activity plot of baseline EEG in wt and 14-3-3ζtg mice. (D, E) Representative spectral activity plot of EEG frequency and amplitude, and quantitative analysis of seizure duration (high amplitude and high frequency discharges) for wt and 14-3-3ζtg mice during the 40 min after intra-amygdala microinjection of kainic acid. No differences were detected between genotypes (n = 6-7 per group).