RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE
Figure 6
Top four most abundant transcripts are shared by SLE patients with the H2 full risk haplotype.
A, Relative abundance ranking of transcripts from 4 healthy donors, 1 SLE patient with the H3 full protective haplotype, and 4 SLE patients with the H2 full risk haplotype is shown. Transcripts were ranked from most to least abundant using MMSeq-generated Gibbs expression estimates; individual transcripts are represented by distinct colors. B, Hierarchial clustering was performed on the nine samples using expression profiles of the 18 IRF5 transcript variants. Height represents the difference between samples. Red values are AU p-values and green values are BP values. Clusters with AU larger than 95% are statistically significant with a p<0.05.